Debunking common myths about Spravato

Spravato is specifically approved for treatment-resistant depression (TRD) and major depressive disorder (MDD) with suicidal thoughts, meaning it is for individuals who haven’t responded to at least two prior antidepressants. It’s not a last resort but rather an option for those needing a different approach to treatment. There are a lot of misconceptions about Spravato®, and we’re here to clear them up. This FDA-approved treatment for treatment-resistant depression is often misunderstood, leading to confusion about how it works and who it’s for. Let’s break down some myths and uncover the real facts so you can make informed decisions about your mental health.

MYTH #1 — Spravato is not covered by insurance

Many insurance plans, including Medicare, do cover Spravato. Our clinic takes care of the entire prior authorization process, working closely with insurers to streamline approvals and ensure a hassle-free experience for our clients.

While some patients feel relief after just a few sessions, most see gradual changes over several weeks. Depression treatment isn’t one-size-fits-all.

MYTH #2 — Spravato is only used as a last-resort treatment

MYTH #3 — Spravato works instantly for everyone

While some patients feel relief after just a few sessions, most see gradual changes over several weeks. Depression treatment isn’t one-size-fits-all.

MYTH #4 — Spravato is just like taking an antidepressant pill

Unlike traditional SSRIs and SNRIs, Spravato works on NMDA receptors, offering a unique and faster-acting approach to treatment-resistant depression.

MYTH #5 — Spravato is addictive like opioids

While Spravato contains esketamine, a derivative of ketamine, it is not the same as recreational ketamine use and does not lead to physical dependence when used as prescribed. Spravato is administered in a controlled medical setting under supervision, greatly reducing the risk of misuse, and patients are carefully screened before starting treatment to ensure it is an appropriate and safe option.

MYTH #6 — Spravato replaces the need for therapy or other treatments

Spravato works best as part of a comprehensive treatment plan. It is not a standalone cure but is most effective when combined with therapy, lifestyle changes, and other medications as needed.

MYTH #7 — Spravato and IV ketamine therapy are the same

Both come from ketamine, but Spravato is FDA-approved, administered as a nasal spray, and requires clinical supervision. IV ketamine is not FDA-approved for depression and follows a different protocol.

MYTH #8 — Spravato is dangerous for everyone with a history of substance use

While Spravato has the potential for misuse, patients with a history of substance use can still be eligible if properly screened and monitored. Providers assess each patient’s history and develop a treatment plan to ensure safe use.